Molecular Docking Simulation of Xanthorrhizol Compounds Derived from Temulawak as Antiinflammatory on Enzymes COX-1 and COX-2
نویسندگان
چکیده
منابع مشابه
Molecular docking and analgesic studies of Erythrina variegata׳s derived phytochemicals with COX enzymes
Secondary metabolites from plants are a good source for the NSAID drug development. We studied the analgesic activity of ethanolic extract of Erythrina variegata L. (Fabaceae) followed by molecular docking analysis. The analgesic activity of Erythrina variegata L. is evaluated by various methods viz., acetic acid-induced writhing test, hot plate and tail immersion test. Subsequently, molecular ...
متن کاملMolecular docking analysis of curcumin analogues with COX-2
Curcumin analogues were evaluated for COX-2 inhibitory as anti-inflammatory activities. The designed analogues significantly enhance COX-2 selectivity. The three compounds could dock into the active site of COX-2 successfully. The binding energies of -8.2, - 7.6 and -7.5 kcal/mol were obtained for three analogues of curcumin respectively. Molecular docking study revealed the binding orientation...
متن کاملMolecular docking studies of withanolides against Cox-2 enzyme.
Withaniasomnifera (Ashwaganda) belonging to the family solanaceae is the subject of our present study. Withanoloides which are the major chemical constituents have been proved of interest because of their structural variations in the hybrids of different races. Docking is the process which brings the two structures together. In the present study we focus the extensive use of tool and grap...
متن کاملIn Silico Analysis of the Potential of the Active Compounds Fucoidan and Alginate Derived from Sargassum Sp. as Inhibitors of COX-1 and COX-2
INTRODUCTION The enzyme cyclooxygenase (COX) is an enzyme that catalyzes the formation of one of the mediators of inflammation, the prostaglandins. Inhibition of COX allegedly can improve inflammation-induced pathological conditions. AIM The purpose of the present study was to evaluate the potential of Sargassum sp. components, Fucoidan and alginate, as COX inhibitors. MATERIAL AND METHODS ...
متن کاملClinical Implications of Cyclooxygenase Enzymes: COX-1/COX-2 Role of the New NSAIDs.
Professor John Vane won the Nobel Prize for elucidating the mechanism of action of aspirin. He reported that this was accomplished by blocking the enzyme called cyclooxygenase (COX-1) that was responsible for the conversion of arachidonic acid to prostaglandins. Prostaglandins liberated from arachidonic acid by cyclooxygenase are short-lived substances that act as local hormones (autocoids) imp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indonesian Journal of Pharmaceutical Science and Technology
سال: 2014
ISSN: 2356-1971,2406-856X
DOI: 10.15416/ijpst.v1i1.7508